As we age the water content of the cartilage decreases as a result the cartilage becomes less resilient.
•Inflammation surrounding the joint can occur.
•The inflammation is usually the result of the cartilage breakdown which is released into the synovial space.
Osteoarthritis can also be caused by other factors such as:
•Obesity (1 lbs of weight loss = nearly 4 lbs of stress relief on the knees).
•Infection of the joint
Osteoarthritis signs and symptoms:
•Pain – during or after movement
•Tenderness – when you apply light pressure
•Stiffness – in the morning or after a period of inactivity
•Loss of flexibility – loss of full range of motion
•Grating sensation – hear or feel when using the joint
•Bone spurs – hard lumps, form around the affected joint
–Sulfate (shrimp shell)
–Hydrochloride (shrimp shell)
A study published in 2009 in Current Therapeutic Research on the use of oral glucosamine sulfate.
–Objective: The aim of the study was to assess the efficacy and tolerability of glucosamine sulfate (GS) in the treatment of knee OA.
–Results: Patient demographics were similar in the GS and placebo groups. Of 60 patients, 56 completed the study. Statistically significant improvements in knee OA were observed, as measured by differences in resting pain at weeks 8, 12, and 16 and in pain during movement at weeks 12 and 16. Drug consumption was lower in the GS group than the placebo group at weeks 8, 12, 16, and 20.
–Conclusions: GS 1500 mg for 12 weeks was associated with statistically significant reductions in pain and improvements in functioning, with decreased pain-relieving consumption, compared with baseline and placebo in these patients with knee OA. A carryover effect was detected after treatment ended.
A study published in 2008 on the use of oral glucosamine hydrochloride
–Objective: To evaluate the results of glucosamine hydrochloride in the treatment of knee degenerative osteoarthritis (DOA).
–Results: The ages of patients ranged from 41 to 67 years with an average age of 57.5 years. The disease course ranged from 6 months to 3 years. Oral glucosamine hydrochloride was given twice a day, each 750 mg, for a 6-week course of treatment; another course of treatment was repeated after 4 months All 60 patients finished treatment, various clinical symptoms for DOA disappeared completely in 31 cases and subsided in 27 cases; the cure rate was 51.7% and the total response rate was 96.7%.
–Conclusion: Glucosamine hydrochloride can benefit knee DOA with symptom-relieving and joint function-improving action.
–Boswellia serrata tree
–65% Boswellic Acid
A study published in 2008 in Arthritis Research & Therapy on the use of oral Boswellia extract.
–Introduction: A 90-day, double-blind, randomized, placebo-controlled study was conducted to evaluate the efficacy of Boswellia extract (30% boswellic acid) in the treatment of osteoarthritis (OA) of the knee.
–Methods: Seventy-five OA patients were included in the study. The patients received either 100 mg (n = 25) or 250 mg (n =25) of Boswellia extract daily or a placebo (n = 25) for 90 days. Each patient was evaluated for pain and physical functions by using the standard tools.
–Results: At the end of the study, both doses of Boswellia extract conferred clinically and statistically significant improvements in pain scores and physical function scores in OA patients. Interestingly, significant improvements in pain score and functional ability were recorded in the treatment group supplemented with 250 mg Boswellia extract as early as 7 days after the start of treatment.
–Conclusion: Boswellia extract reduces pain and improves physical functioning significantly in OA patients. Boswellia extract may exert its beneficial effects by controlling inflammatory responses through reducing pro-inflammatory modulators, and it may improve joint health by reducing the enzymatic degradation of cartilage in OA patients.
–Biologically-active mineral sulfur
–Passes through cellular membranes of the body.
–It dilates blood vessels (vasodilation) and increases blood flow.
–Reduces muscle spasm. Injury or inflammation commonly cause spasm in a muscle or group of muscles. Spasm involves a sudden contraction, which is followed by pain and interference with function. MSM taken orally produces a muscle-relaxing effect.
–Alters the cross-linking process in collagen, thus reducing scar tissue. Cross-linking is the process in which new structural proteins are knitted to existing healthy tissue.
–It has an immune normalizing effect, as observed in some autoimmune diseases such as rheumatoid arthritis.
–Provides sulfur which is needed for the structural integrity of joint cartilage and connective tissue.
–AIM’s MSM has been shown in research to inhibit inflammation by decreasing influx of certain white blood cells.
–Reduced inflammation increases circulation to aid recovery of sore muscles.
A study published in 2006 in Osteoarthritis and Cartilage on the use of oral methylsulfonylmethane.
-Methods: A randomized, double-blind, placebo-controlled trial was conducted. Fifty men and women, 40-76 years of age with knee OA pain were enrolled in an outpatient medical center. Intervention was MSM 3 g or placebo twice a day for 12 weeks (6 g/day total).
-Results: Compared to placebo, MSM produced significant decreases in osteoarthritis pain and physical function impairment. MSM also produced improvement in performing activities of daily living when compared to placebo on overall health-relate quality of life evaluation.
-Conclusion: MSM (3 g twice a day) improved symptoms of pain and physical function during the short intervention without major adverse events.
MSM / Glucosamine
A study published in 2004 in Clinical Drug Investigation on the use of oral glucosamine and methylsulfonylmethane.
•Objective: The aim of the study was to compare the efficacy and safety of oral glucosamine (Glu), methylsulfonylmethane (MSM), their combination and placebo in osteoarthritis of the knee.
•Patients and design: A total of 118 patients of either sex with mild to moderate osteoarthritis were included in the study and randomised to receive either Glu 500mg, MSM 500mg, Glu and MSM or placebo capsules three times daily for 12 weeks.
•Results: Glu, MSM and their combination significantly improved signs and symptoms of osteoarthritis compared with placebo. The combination treatment resulted in a more significant decrease in the mean pain index. After 12 weeks, the mean swelling index significantly decreased with Glu and MSM, while the decrease in swelling index with combination therapy was greater after 12 weeks.
•Conclusion: Glu, MSM and their combination produced an painkilling and anti-inflammatory effect in osteoarthritis. Combination therapy showed better efficacy in reducing pain and swelling and in improving the functional ability of joints than the individual agents. The onset of painkilling and anti-inflammatory activity was found to be more rapid with the combination than with Glu. It can be concluded that the combination of MSM with Glu provides better and more rapid improvement in patients with osteoarthritis.
Q: May children and pregnant women take Frame Essentials?
A: There should be no reason for children to be using this product. Pregnant women should consult a health practitioner.
Q: May I take Frame Essentials with other medications?
A: There are no indications that glucosamine interacts with other medications. Of course, you should always consult a health practitioner when adding new supplements to your regimen.
Q: Is glucosamine actually absorbed?
A: Yes, in one study on glucosamine sulfate (pill form), ninety percent of the glucosamine was absorbed.
Q: Does Frame Essentials have any side effects?
A: Glucosamine and MSM is safe. A few people have reported upset stomach and nausea. In a year of formal testing of glucosamine, no significant side effects were found
materials By Phil Jermann